MRI detection of new hemorrhages: Potential marker of progression in cerebral amyloid angiopathy
- 1 September 1999
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 53 (5) , 1135
- https://doi.org/10.1212/wnl.53.5.1135
Abstract
Article abstract The authors used serial gradient-echo MRIs to detect new small hemorrhages in patients with previous lobar hemorrhage. Of 24 lobar hemorrhage patients (17 diagnosed with probable and 7 with possible amyloid angiopathy) who prospectively underwent repeat MRI 1.5 years after initial study, 9 (38%) demonstrated additional hemorrhages at follow-up. Interrater agreement was high. New hemorrhages were more frequent in patients with probable amyloid angiopathy (8 of 17, 47%) with more hemorrhages at baseline (p < 0.01). These results suggest a role for gradient-echo MRI in assessing disease progression in amyloid angiopathy.Keywords
This publication has 7 references indexed in Scilit:
- MRI evidence of past cerebral microbleeds in a healthy elderly populationNeurology, 1999
- Apolipoprotein E ε4 Is Associated With the Presence and Earlier Onset of Hemorrhage in Cerebral Amyloid AngiopathyStroke, 1996
- Petechial hemorrhages accompanying lobar hemorrhageNeurology, 1996
- Hereditary Cerebral Hemorrhage with Amyloidosis- DutchType: Better Correlation of Cognitive Deterioration with Advancing Age than with Number of Focal Lesions or White Matter HyperintensitiesAlzheimer Disease & Associated Disorders, 1996
- Recurrence of Bleeding in Patients With Primary Intracerebral HemorrhageStroke, 1995
- The clinical spectrum of cerebral amyloid angiopathyNeurology, 1993
- Cerebral amyloid angiopathy. A critical review.Stroke, 1987