Lymphocyte studies in a patient with chronic polyradiculoneuropathy

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Abstract
Immunologic abnormalities were studied in 1 patient with chronic polyradiculoneuropathy. The effects of immune suppression and plasmapheresis on the clinical course and immune abnormalities were also studied. Increased helper T cells and B cells with deficiency of T suppressor cells to B-cell but not to T-cell targets were detected. The patient''s blood lymphocytes, but not the control''s lymphocytes, proliferated in vitro on culturing them with P2 antigen in the presence of the patient''s CSF. Plasmapheresis combined with corticosteroid and azathioprine reversed the majority of immune abnormalities to normal but did not decrease the patient''s lymphocyte-P2 proliferative responses or improve clinical status.

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