Untersuchung einiger Pyrrolizidinalkaloide auf chromosomenschädigende Wirkung in menschlichen Lymphocytenin vitro

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Abstract
The pyrrolizidine alkaloids senkirkine and tussilagine, which occur in the aerial parts of the medicinal plant Tussilago fargara, were investigated for their ability to induce chromosome damage in human lymphocytes in vitro. Up to concentrations of 1000 .mu.M the 2 alkaloids did not enhance the number of structural chromosome aberrations. Heliotrine, a pyrrolizidine alkaloid used for comparison, induced chromosomal aberrations when tested at a concentration of 100 .mu.M. Heliotrine was capable of damaging the chromosomes of unstimulated lymphocytes, i.e., G0-phase lymphocytes.

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