Studies of Topical Carbonic Anhydrase Inhibitors: Ocular Hypotensive Effect of Thiadiazole Derivatives
- 1 January 1993
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Ocular Pharmacology and Therapeutics
- Vol. 9 (2) , 109-115
- https://doi.org/10.1089/jop.1993.9.109
Abstract
A series of thiadiazole derivatives were topically applied in gels or suspensions to rabbits to determine their ocular hypotensive effect. As a result, the compounds with higher corneal permeabilities showed stronger effect in lowering IOP. In addition, gels also caused stronger effect than suspensions. Different concentrations of gel preparations produced diverse ocular hypotensive effects. A linear relationship between the integrated IOP response and logarithm concentration of inhibitor was found. It is proposed that the ocular hypotensive effect was attributed to the level of inhibitor in ciliary body.Keywords
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