Basophilic Leukocytes in Delayed Hypersensitivity Reactions

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Abstract
In guinea pigs, basophilic leukocytes constitute a high proportion of the cells infiltrating allergic contact, Jones-Mote and tuberculin-like reactions, when elicited 1 week after sensitization with 2,4 dinitrofluorobenzene, ovalbumin (OA) in Freund's incomplete adjuvant (FIA) and OA in Freund's complete adjuvant (FCA), respectively. When animals are pretreated with one dose (300 mg/kg) of cyclophosphamide, 3 days before sensitization, allergic contact and Jones-Mote reactions, elicited 7 days after sensitization, are increased in intensity and induration and prolonged, whereas the tuberculin-like reactions are somewhat reduced in intensity. The percentages of basophils infiltrating all these altered reactions are markedly reduced. Thus, delayed-in-onset skin reactions may occur in guinea pigs immunized with proteins in FIA or FCA or in contact-sensitized animals in the presence or absence of basophils.

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