Effect of Acute Treatment with Sodium Valproate on Catecholamine and Serotonin Synthesis in Mouse Cerebral Cortex
- 1 January 1995
- journal article
- research article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 32 (3) , 124-127
- https://doi.org/10.1159/000119224
Abstract
We examined the effect of sodium valproate (VPA) on monoamine synthesis in the mouse cerebral cortex by measuring the accumulation of L-3,4-dihy-droxyphenylalanine and 5-hydroxytryptophan following inhibition of aromatic L-amino acid decarboxylase. Treatment with VPA decreased catecholamine synthesis, in a dose-dependent manner, with maximum inhibition 60 min following treatment. Muscimol, a GABAA receptor agonist, also decreased catecholamine synthesis, although baclofen, a GABAB receptor agonist, did not. Picrotoxin, a GABAAreceptor antagonist, inhibited the VPA-induced decrease in catecholamine synthesis. However, serotonin synthesis was not significantly changed by VPA. These results suggest that acute treatment with VPA reduces the synthesis of catecholamines via GABAA receptors.Keywords
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