Cerebral Blood Flow and Metabolism during Morphine -Nitrous Oxide Anesthesia in Man

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Abstract
The effects of 2 levels of morphine-N2O anesthesia on cerebral blood flow (CBF) and cerebral metabolism (CMRO2) were measured in healthy male volunteers. CBF and metabolic measurements were made in the awake control state, after morphine, 1 mg/kg, with 70% N2O and 30% O2, and at a total dose of 3 mg/kg morphine with the same concentrations of N2O and O2. Ventilation was controlled and CO2 added to inspired gas to maintain PaCO2 [arterial CO2 tension] constant at 40 torr. CBF was 48.2 .+-. 4.4 (SEM [standard error of the mean]) ml/100 g per min during the control phase; 45.7 .+-. 6.4 ml/100 g per min after 1 mg/kg morphine, and 44.3 .+-. 4.9 ml/100 g per min after 3 mg/kg morphine. The latter values are not significantly different from control. Cerebral metabolic rates for O2, glucose and lactate were normal in the control phase and did not change significantly when morphine was present at either level. Morphine-N2O anesthesia produces no alteration of CBF or metabolism in normal man at the 2 dose levels studies.

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