Highly regio- and stereo-selective alkyl substitution with copper reagents for the construction of chiral trifluoromethylated quaternary carbon centres
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 16,p. 1497-1498
- https://doi.org/10.1039/a703223d
Abstract
A new route for the asymmetric construction of quaternary carbon centres containing a trifluoromethyl group has been established using a highly regio- and stereo-selective S N 2′ reaction of organocopper and organocuprate reagents with allylic mesylates 4 and 8.Keywords
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