DUODENAL ULCER

1 May 1928

journal article
research article
Published by American Medical Association (AMA) in Archives of internal medicine (1908)

Vol. 41 (5) , 633-641
https://doi.org/10.1001/archinte.1928.00130170020003

Abstract

Various hypotheses have been advanced in explanation of the pain in duodenal ulcer. This pain has been ascribed to irritation of exposed nerve endings in the ulcer base by the acid gastric juice, or to sensitization of the pain-producing mechanism in some way by acid. Bonninger,¹Palmer²and others hold such views. Mechanical irritation by coarse particles of food is the cause assigned by Pick.³Spasm of the pyloric sphincter or of the duodenal cap has been put forward by Glaessner and Kreuzfuchs⁴and many others. Tension, due to an inhibition of relaxation of the pyloric sphincter, combined with strong gastric peristalsis, has been advanced by Hurst⁵as the cause. That distention of the stomach is an important element in the pain of gastric ulcer and that this pain is readily relieved by passing a tube into the stomach is stated by Poulton.⁶That the pain is possibly due to

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