RECRUITMENT OF EFFECTOR LYMPHOCYTES BY INITIATOR LYMPHOCYTES - RECRUITED LYMPHOCYTES ARE IMMUNOSPECIFIC AND INCLUDE GRAFT-VERSUS-HOST-REACTIVE LYMPHOCYTES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (2) , 614-619
Abstract
Initator T [thymus-derived] lymphocytes (ITL) [mouse], sensitized in vitro against [mouse] fibroblast antigens, recruit effector T cells in vivo. After injection into hind foodpads of syngeneic recipients, sensitized ITL migrated to the draining popliteal lymph nodes (PLN) and activated a trapping mechanism by which circulating lymphocytes were recruited in the PLN. Experiments designed to test the immunospecificity of these recruited T lymphocytes (RTL) are reported. Immunospecific RTL were depleted from other lymphoid organs during recruitment in the PLN; immunospecific ITL were not depleted from spleens during PLN recruitment. Thus ITL and RTL are functionally distinguishable. Specific GVH [graft vs. host] reactive lymphocytes were also lost from spleens and distal lymph nodes during trapping of RTL in the PLN. Thus, the trapping phase of the recruitment response is immunospecific, as are the sensization and effector phases. The trapped RTL are antigen-specific, and include the pool of GVH-reactive-lymphocytes committed to the same alloantigen. GVH-reactive cells apparently respond to syngeneic ITL sensitized against allogeneic fibroblasts.

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