Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-aged Men

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Abstract
The role of uric acid as an independent marker of cardiovascular risk has been controversial for decades. At physiologic pH values, serum monoanionic uric acid is the major product of purine metabolism in humans and higher primates and is formed from xanthine, a reaction catalyzed by xanthine dehydrogenase/oxidase.1,2 Several epidemiologic studies have shown elevated uric acid levels to predict increased risk of cardiovascular events,3-12 although lack of an independent relationship has also been found.3,10