Studies on the Effect of DL-Glyceric Aldehyde on the Dental Caries Activity in White Rats and Cotton Rats

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Abstract
Addition of increasing amts. of DL-glyceric aldehyde to saliva results in progressive decreases in acid formation during incubation (Fosdick and Calandra, Jour. Dental Res. 26: 309. 1947.) To demonstrate whether DL-glyceric aldehyde had an ability to inhibit the development of carious lesions in exptl. animals, this material was incorporated into a purified caries-producing diet at levels of 0.5, 1 and 2% After 14 weeks on these regimens, white rats (Mus norvegicus) and cotton rats (Sigmondon h. hispidus) fed varying levels of racemic glyceric aldehyde developed the same avg. number and extent of carious lesions as the control animals fed only the caries-producing diet. The question was raised as to whether in vitro tests for inhibiting action on acid production would be related to the in vivo ability to prevent the development of carious lesions.

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