Effects of B‐HT 920 and B‐HT 933 on Dopamine and Noradrenaline Autoreceptors in the Rat Brain
- 1 January 1983
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 52 (1) , 51-56
- https://doi.org/10.1111/j.1600-0773.1983.tb01075.x
Abstract
B-HT 920 at low doses inhibited the accumulation of DOPA following treatment with reserpine and a DOPA decarboxylase inhibitor in the dopamine-, but not in the noradrenaline-predominant regions of the rat brain. B-HT 933 selectively inhibited this DOPA accumulation in the noradrenaline-predominant regions. These effects of B-HT 920 and B-HT 933 were completely antagonized by haloperidol and yohimbine, respectively. The rat motor activity was reduced by B-HT 920 and it was restored following apomorphine. B-HT 933 decreased the motor activity by a yohimbine-sensitive mechanism. The results indicate that B-HT 920 can selectively and potently stimulate the dopamine autoreceptors whereas B-HT 933 can selectively stimulate the noradrenaline autoreceptors.Keywords
This publication has 18 references indexed in Scilit:
- Pharmacological profiles of the putative dopamine autoreceptor agonists 3-PPP and TL-99European Journal of Pharmacology, 1981
- 3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptorsLife Sciences, 1981
- Modulation of motor activity by ?1 and ?2 stimulation in miceNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1981
- Neurochemical and Behavioral Evidence for a Selective Presynaptic Dopamine Receptor AgonistScience, 1980
- Investigation into different types of post- and presynaptic α-adrenoceptors at cardiovascular sites in ratsEuropean Journal of Pharmacology, 1980
- DETERMINATION OF CATECHOLAMINES IN RAT BRAIN PARTS BY REVERSE‐PHASE ION‐PAIR LIQUID CHROMATOGRAPHYJournal of Neurochemistry, 1978
- Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the ?Clonidine-type?Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- Thyroxine and brain catecholamines: Increased transmitter synthesis and increased receptor sensitivityBrain Research, 1974
- Evidence for dopamine receptor stimulation by apomorphineJournal of Pharmacy and Pharmacology, 1967
- A Multiple Comparison Procedure for Comparing Several Treatments with a ControlJournal of the American Statistical Association, 1955