Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork.
Open Access
- 1 July 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (7) , 2266-2269
- https://doi.org/10.1073/pnas.73.7.2266
Abstract
The deposition site of newly synthesized histone was studied in rat hepatoma cells. It appears to be randomly distributed over the chromosomal material and does not become associated specifically with immediately post-replicational DNA, nor is it deposited in discrete continuous regions distal to the sites of DNA synthesis. The newly synthesized DNA rapidly acquires a complement of chromosomal proteins; presumably, preexisting histones must migrate to become associated with post-replicational DNA.This publication has 16 references indexed in Scilit:
- Temporal relationships of chromatin protein synthesis, DNA synthesis, and assembly of deoxyribonucleoprotein.Proceedings of the National Academy of Sciences, 1976
- Deposition of histones onto replicating chromosomes.Proceedings of the National Academy of Sciences, 1975
- Processing of Newly Synthesized Histone MoleculesScience, 1975
- Effects of cycloheximide on chromatin biosynthesisJournal of Molecular Biology, 1975
- Separation of newly synthesized nucleohistone by equilibrium centrifugation in cesium chlorideBiochemistry, 1974
- On the Translational Control of Histone SynthesisEuropean Journal of Biochemistry, 1974
- Identification of a distinction between cytoplasmic histone synthesis and subsequent histone deposition within the nucleusBiochemistry, 1974
- DNA Replication Sites within Nuclei of Mammalian CellsNature, 1973
- Sites of Replication of Chromosomal DNA in a Eukaryotic CellProceedings of the National Academy of Sciences, 1972
- The Structure and Function of ChromatinPublished by Springer Nature ,1972