Effect of Ascorbic Acid on Desferrioxamine-Induced Urinary Iron Excretion in Idiopathic Hemochromatosis

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Abstract
The effect on urinary Fe excretion (UIE) of vitamin C administered orally 2 h after the start of an 8 h deferrioxamine (DF) i.v. infusion was studied in 12 patients with untreated idiopathic hemochromatosis (IH). Mean .+-. SEM [standard error of the mean] basal UIE of 324.6 .+-. 84.6 .mu.g/24 h increased after a 1 g i.v. DF infusion of 8778.5 .+-. 1191.4 .mu.g/ 24 h; when vitamin C 1 or 2 g were added to DF i.v. infusion, there were further increases to 11,241.5 .+-. 1486.1 (P < 0.01) and 13,531.2 .+-. 1697.2 .mu.g/24 h (P < 0.05 vs. the last value), respectively. Basal UIE did not significantly increase after oral vitamin C administration alone. No side effects were observed.