PROLIFERATION OF PERIPHERAL LYMPHOID CELLS FROM EUTHYROID AND HYPERTHYROID INDIVIDUALS CULTURED WITH HUMAN THYROGLOBULIN

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Abstract
Peripheral lymphoid cells from euthyroid and hyperthyroid subjects were tested for proliferative responses to human thyroglobulin in vitro using [3H]thymidine incorporation as assay. Non-fractionated lymphoid cells from both groups displayed weak stimulation. Using a rosette technique for separating sub-populations of lymphoid cells it was concluded that T [thymus-derived] cells constituted the responding cells. Both hyperthyroid and euthyroid subjects apparently possess clones of T cells which are reactive against human thyroglobulin.

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