Total synthesis from L-quebrachitol of the D-myo-inositol 1,4,5-trisphosphate analogue, L-chiro-inositol 2,3,5-trisphosphate, a potent inositol 1,4,5-trisphosphate 5-phosphatase and 3-kinase inhibitor
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 1014-1016
- https://doi.org/10.1039/c39910001014
Abstract
A concise synthesis of L-chiro-inositol 2,3,5-trisphosphate, a novel receptor agonist and a potent inhibitor of the metabolic enzymes which act upon D-myo-Inositol 1,4,5-trisphosphate, is reported using methodology which accomplishes the required regio-protection of L-chiro-inositol for phosphorylation in one step.Keywords
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