A Mechanism for the Suppression of Ongoing IgE Synthesis
- 1 January 1987
- journal article
- regulation of-ige-mediated-disorders
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 82 (3-4) , 414-416
- https://doi.org/10.1159/000234242
Abstract
IgE synthesis from the human plasmacytoma U266/AF-10 was suppressed by addition of IgE immune complexes (IgE-IC). This suppression was isotype-specific as synthesis from other B cell lines was unaffected. Using IgE-IC constructed with a monoclonal antibody that recognizes PS protein-IgE and not ND IgE (the IgE protein made by U266/AF-10), we have shown that this suppression was mediated through the cross-linking of the Fc epsilon receptor.Keywords
This publication has 0 references indexed in Scilit: