Water Based Silicone Elastomer Controlled Release Tablet Film Coating III - Drug Release Mechanisms

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Abstract
The release of potassium chloride from polyethylene glycol-silicone elastomer coated tablets was achieved by the diffusion through water-filled pores formed in the hydrated coating and the osmotic pumping generated by the saturated salt solution. The relative contribution of these two mechanisms to the overall drug release rate was shown to be a function of the polyethylene glycol loading in the coating. As the polyethylene glycol loading level increased, the transpore diffusion became the predominant release mechanism. The capability of the polyethylene glycol-silicone elastomer coatings to provide controlled release for therapeutic agents of different water solubilities and dose levels was also demonstrated. Both the rate and extent of release of the active ingredients could be altered by the type of diluent used in the tablet matrix

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