The effect of haemorrhage on the incorporation of [α−14C]glycine into stercobilin

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Abstract
The incorporation of a-C14[long dash]glycine into the early-labeled ("hemopoietic") stercobilin was studied in man before and after hemopoiesis had been stimulated by bleeding. The radioactivity of stercobilin formed after hemorrhage was consistently greater than the radioactivity of that formed in the corresponding period before hemorrhage, showing that the hemopoietic stercobilin is related to the rate of production of red cells. The subject studied was suffering from a mild form of porphyria cutanea tarda. A comparison of the specific activities of stercobilin excreted between days 1 and 34, and 129 and 157 days after the first feeding of glycine, confirmed of the findings of other workers that there was no increase in the amount of hemopoietic stercobilin relative to late-labeled stercobilin such as occurs in congenital porphyria.