Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. I. Role of Fc?RI cross-linking stimulation

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Abstract
This study demonstrates that immunodepressed trauma patients' monocytes produce elevated interleukin-6 to adherence, bacterial, and cytokine stimulation compared to immunocompetent trauma patients' or normals' monocytes, suggesting theirin vivo preactivation possibly mediated by the hyperimmunoglobulinemia which characterizes these patients. Furthermore, stimulation of monocytes through cross-linking their FcγRI induces and augments interleukin-6 (IL-6) production to subsequent stimulation both in trauma patients' (PPγRI-bearing monocytes in their total monocyte population and here we show that those FcγRI+ monocytes produce significantly elevated interleukin-6, suggesting a relationship between elevated monocyte interleukin-6 production and FcγRI triggering. Interleukin-6 induction by FcRI stimulation is not mediated solely by FcRI-induced MØ tumor necrosis factor alpha, IL-1α, or IL-1β production and is independent of MØ prostaglandin E2 levels. Therefore, FcRI stimulation-induced elevated MØ IL-6 might contribute to the increased immunoglobulin levels posttrauma.