Bioassay of Oestrogen Using Sheep

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Abstract
The quantitative assay of estrogen has been investigated using immature ewes and wethers and adult ovariectomized ewes. Stilbestrol dipropionate was administered at several dosage levels for varying periods, and uterine and cervical weights in the ewes and bulbo-urethral gland weights in the wethers were obtained at slaughter. A 3-day injection period in ovariectomized ewes, using the uterine weight response, gave an assay of high precision and sensitivity.