Effect of Beta-Sitosterol on Regression of Hypercholesterosis and Atherosclerosis in Chickens.

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Abstract
A previously elevated cholesterol concentration in liver, serum, and aorta of the chicken was reduced by administration of beta-sitosterol in the presence or absence of dietary cholesterol, or by the withdrawal of dietary cholesterol. The resulting tissue cholesterol concentrations always approached normal values. When beta-sitosterol was fed in the diet, total sterol content of liver, serum, and aorta was slightly lower than in birds fed the diet free of either cholesterol or beta-sitosterol. Atheroma regression of the chicken was accomplished by giving beta-sitosterol in the presence of dietary cholesterol, or by withdrawing dietary cholesterol. Atheroma regression in the chicken was paralleled by a decreased cholesterol concentration of the blood and liver.