Inhibition of cholinergic histamine release in rat mast cells
- 1 April 1980
- journal article
- histamine and-kinins
- Published by Springer Nature in Inflammation Research
- Vol. 10 (1-2) , 139-140
- https://doi.org/10.1007/bf02024196
Abstract
Adrenaline inhibits the acetylcholine-evoked histamine release from isolated purified rat mast cells, in a dose-dependent fashion. The inhibitory effect of adrenaline is reversed by preincubating the cells with a beta-blocker, alprenolol, but not by preincubating them with an alpha-blocker, phentolamine. These results were confirmed by observations using an electron microscope and they suggest that adrenaline inhibits the cholinergic histamine release from rat mast cells acting upon beta-receptors.Keywords
This publication has 9 references indexed in Scilit:
- Cholinergic histamine release: Evidence of muscarinic receptors in rat mast cellsInflammation Research, 1979
- Release of histamine from rat mast cells by acetylcholineNature, 1978
- Modulation of the spontaneous histamine release by adrenergic and cholinergic drugsInflammation Research, 1978
- Inhibitory role of cyclic adenosine 3′5′-monophosphate in histamine release from rat peritoneal mast cells in vitroBiochemical Pharmacology, 1976
- Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic, and physical stimuli.1975
- Modulation of Cyclic AMP in Purified Rat Mast CellsThe Journal of Immunology, 1975
- A procedure for the determination of histamineBiochimica et Biophysica Acta, 1961
- Isolation of “biologically intact” mast cellsExperimental Cell Research, 1959
- A METHOD FOR THE FLUOROMETRIC ASSAY OF HISTAMINE IN TISSUES1959