Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia
- 16 December 2002
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 118B (1) , 20-24
- https://doi.org/10.1002/ajmg.b.10053
Abstract
Dysregulation in dopaminergic neurotransmission might play a role in the pathogenesis of schizophrenia, and therefore genetic components of the dopamine (DA) pathway may confer risk. The NR4A2 (Nurr1) gene is essential for the development and maintenance of mesencephalic DA‐synthesizing neurons. Moreover, Nurr1 forms a heterodimer with the retinoid X receptor and disturbances in the retinoid‐signaling cascade may be involved in susceptibility to schizophrenia. To investigate the potential genetic contribution of NR4A2, we performed a case‐control association study using three common variants in the gene [−2922(C)2‐3, IVS6 + 17∼+18insG, EX8 + 657(CA)9‐10] that were in strong linkage disequilibrium with each other. We did not detect a significant allelic or genotypic association. Haplotypes derived from all three polymorphisms generated similar results. These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals.Keywords
This publication has 19 references indexed in Scilit:
- Recent advances in the genetics of schizophreniaCellular and Molecular Life Sciences, 2002
- Mutation analysis of the retinoid X receptor beta, nuclear‐related receptor 1, and peroxisome proliferator‐activated receptor alpha genes in schizophrenia and alcohol dependence: Possible haplotype association of nuclear‐related receptor 1 gene to alcohol dependenceAmerican Journal of Medical Genetics, 2002
- Are Rare Variants Responsible for Susceptibility to Complex Diseases?American Journal of Human Genetics, 2001
- Selective Agenesis of Mesencephalic Dopaminergic Neurons in Nurr1-Deficient MiceExperimental Neurology, 1999
- Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1Molecular Endocrinology, 1996
- Monte Carlo tests for associations between disease and alleles at highly polymorphic lociAnnals of Human Genetics, 1995
- Cholinergic differentiation of cultured sympathetic neurons induced by retinoic acidFEBS Letters, 1994
- Expression of Ionotropic Glutamate Receptor Genes by P19 Embryonal Carcinoma CellsBiochemical and Biophysical Research Communications, 1993
- Retinoic acid induces cholinergic differentiation of cultured newborn rat sympathetic neuronsJournal of Neuroscience Research, 1993