EFFICACY OF IMMUNOSERODIAGNOSTIC PROCEDURES IN THE RECOGNITION OF CANINE IMMUNOLOGICAL DISEASES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (10) , 1662-1666
Abstract
Six immunologic tests were conducted on a large population of dogs with a variety of diseases. The test results were analyzed retrospectively and correlated to the clinical and final pathologic diagnoses. Rheumatoid factor and the direct antiglobulin (Coombs) test were sensitive and specific for the diagnoses of canine rheumatoid arthritis and autoimmune hemolytic anemia. The antinuclear antibody test was useful in supporting the diagnosis of systemic lupus erythematosus (SLE) only when the antibody titer and staining pattern were taken into consideration. The lupus erythematosus cell test was specific but not sensitive when used to confirm a diagnosis of canine SLE. Cellulose acetate serum electrophoresis and immunoelectrophoretic techniques were useful in supporting the diagnosis of multiple myeloma. Dogs with primary immunologic disease had a poor prognosis. A female predisposition was observed in cases of canine autoimmune hemolytic anemia and SLE. Ovariectomy seemed to prevent the development of canine SLE.

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