Osteofibrous dysplasia in a Japanese boy with Costello syndrome
- 1 July 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Clinical Dysmorphology
- Vol. 12 (3) , 211-212
- https://doi.org/10.1097/00019605-200307000-00016
Abstract
We present the case of a boy with Costello syndrome who developed osteofibrous dysplasia during a phase of growth hormone therapy. The lesion and the accompanying pain disappeared after discontinuation of the therapy. Growth hormone is a known mitogen for some neoplasms and osteofibrous dysplasia has been reported to become aggressive. Thus, although osteofibrous dysplasia in Costello syndrome has not been reported before, growth hormone therapy should be used under close supervision in children with this syndrome.Clin Dysmorphol12:211-212 © 2002 Lippincott Williams & Wilkins.Keywords
This publication has 3 references indexed in Scilit:
- Five additional Costello syndrome patients with rhabdomyosarcoma: Proposal for a tumor screening protocolAmerican Journal of Medical Genetics, 2002
- Growth hormone deficiency in Costello syndrome: A possible explanation for the short statureThe Journal of Pediatrics, 2001
- Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for histopathogenesis and its relationship with adamantinomaCancer, 1994