The Immunochemistry of Allergens
Open Access
- 1 June 1943
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 46 (6) , 347-365
- https://doi.org/10.4049/jimmunol.46.6.347
Abstract
Summary: Antigenic relationships of previously described electrophoretic fractionation products of the allergenic protein-carbohydrate fraction CS-1A from cottonseed were studied by the Dale method. Fraction CS-51R (picric acid-precipitable cathodic fraction) was found to be antigenically indistinguishable from CS-56R (picric acid-precipitable anodic fraction). Fraction CS-56S, separated from the mother liquor in the picric acid fractionation of the anodic fraction, was found to contain antigen unrelated to CS-51R or CS-56R. A refractionated carbohydrate-free cathodic fraction, CS-60C, was antigenically indistinguishable from CS-51R. Hence carbohydrate plays no apparent role in determining antigenic specificity. The antigenic specificity of fractions CS-51R and CS-56R was not altered by the procedure of isolation. Thus they appear to be preformed native proteins.Keywords
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