Relationships between crystallinity of .BETA.-cyclodextrin and tablet characteristics.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (11) , 5110-5112
- https://doi.org/10.1248/cpb.33.5110
Abstract
The effects of the crystallinity of .beta.-cyclodextrin (.beta.-CD) on the hardness, apparent density and disintegration time of .beta.-CD tablet has been studied. .beta.-CD powders with various degrees of crystallinity were prepared by grinding and used for tableting. The crystallinity was measured by the X-ray diffraction method. Linear relationships were found between tablet compression force and tablet hardness. It was also observed that decreasing crystallinity caused an increase of tablet hardness was well as disintegration time. The results indicate that crystallinity is one of the important factors controlling tablet characteristics.This publication has 1 reference indexed in Scilit:
- Physicochemical properties of crystalline lactose. II. Effect of crystallinity on mechanical and structural properties.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984