A GRANULOCYTE REACTIVE MONOCLONAL-ANTIBODY, 1G10, IDENTIFIES THE GAL-BETA-1-4(FUC-ALPHA-1-3)GLCNAC (X-DETERMINANT) EXPRESSED IN HL-60 CELLS ON BOTH GLYCOLIPID AND GLYCOPROTEIN MOLECULES
- 1 January 1983
- journal article
- research article
- Vol. 62 (5) , 1022-1026
Abstract
1G10, a monoclonal IgM antibody that identifies a differentiation antigen on human granulocytes and a subpopulation of monocytes, was found to react specifically with glycosphingolipids bearing the Gal.beta.1-4(Fuc.alpha.1-3)GlcNAc hapten (X determinant). This carbohydrate determinant was found on both glycolipid and glycoprotein molecules isolated from HL-60 cells (a [human] promyelocytic leukemia cell line). Thus, this highly conserved carbohydrate-defined determinant previously described on mouse embryonic and mouse and human carcinoma cells is also expressed as a tissue-specific differentiation antigen on normal human granulocytes.This publication has 20 references indexed in Scilit:
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