Brain Glutamic Acid Decarboxylase Activity in Parkinson’s Disease
- 1 January 1974
- journal article
- Published by S. Karger AG in European Neurology
- Vol. 12 (1) , 13-19
- https://doi.org/10.1159/000114599
Abstract
The activity of glutamic acid decarboxylase (GAD), the enzyme involved in formation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), was studied in autopsy brain samples from six parkinsonian patients and 13 controls. There was relatively good postmortem stability of GAD in deep-frozen brain samples over a 3-week period. The activity of GAD was significantly reduced in brain samples of patients with Parkinson’s disease, being about 50% of that in controls. Moreover, levodopa treatment showed a tendency to increase the activity of GAD. The results suggest the involvement of GABA neurons in Parkinson’s disease.Keywords
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