COMPARISON OF OVARIAN AND PITUITARY HORMONESFOR MAINTENANCE OF PREGNANCY IN PYRIDOXINE-DEFICIENT RATS1

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Abstract
Previous studies have shown that the addition of a potentB6-antagonist, desoxypyridoxine, to a purified B6-deficient diet will result in the rapid production of a B6-deficiency in adult rats (Nelson and Evans, 1948, 1951). Acrodynia of,the paws, a characteristic sign of the deficiency, and marked reproductive disturbances, namely a high incidence of resorptions, occurred after 2–3 weeks of the deficient diet. Pregnancy was maintained in such B6-deficient rats by administration of both estrone and progesterone but not by either hormone separately (Nelson, Lyons, and Evans, 1951), indicating some similarity between these B6-deficient rats and hypophysectomized-oophorectomized rats in which pregnancy can be maintained by the combination of the same hormones at the same dosage levels (Lyons, 1943). To determine whether pituitary or ovarian dysfunction is involved in the hormonal inadequacies of the B6-deficient rat, the three pituitary gonadotrophins which maintain pregnancy in the hypophysectomized rat have been tested in the vitamin-deficient rats.

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