Decomposition of 3-Hydroxyanthranilic Acid Under Simulated Physiologic Conditions.

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Abstract
Summary The stability of 3-hydroxyanthranilic acid (3-HOA) in buffer solutions was investigated as it relates to pH, oxygen tension, and catalytic ion concentrations. The data show that 3-HOA is unstable under certain simulated physiologic conditions, and suggest that the amounts found in some samples of voided urine are not necessarily the true quantities formed, but rather may be the amounts remaining after decomposition of the metabolite in the interim between formation and analysis.