Adaptation of methicillin-resistant Staphylococcus aureus during antibiotic therapy
- 1 June 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 23 (6) , 923-927
- https://doi.org/10.1093/jac/23.6.923
Abstract
Colonization of a patient by methicillin-resistant Staphylococcus aureus (MRSA) of a single phage-type for over four years is described. During this period we observed the appearance and disappearance of resistance to erythromycin, clindamycin, gentamicin, kanamycin, tobramycin, neomycin and mupirocin. We also saw stepwise increases in methicillin resistance and reversible changes in physical appearance and the colonizer pathogen role. Correlation of clinical observations, details of antibiotic therapy and laboratory studies demonstrated that adaptation of MRSA during antibiotic therapy favoured MRSA establishment and predominance.Keywords
This publication has 1 reference indexed in Scilit:
- The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporinsJournal of Clinical Microbiology, 1986