URINARY CATECHOLAMINES AND AMPHETAMINE EXCRETION IN HYPERACTIVE AND NORMAL BOYS

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Abstract
Urinary catecholamines and metabolites and urinary amphetamine excretion were examined for hyperactive and normal boys following a single dose of d-amphetamine (0.5 mg/kg) and placebo. Hyperactive children had a significantly faster rate of excretion of amphetamine which could not be accounted for by previous exposure to drug or by signs of neurological involvement. Urinary norepinephrine (NE) was signficantly higher for hyperactive than for normal children, but NE excretion did not correlate with motor activity or any measures of arousal. The single dose of amphetamine produced a significant rise in urinary epinephrine excretion (EP) for the normal children but not for the hyperactive group. Apparently a more sluggish catecholamine response to stimulants occurs for hyperkinetic children.