Treatment of Herpesvirus Infections

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Abstract
CytomegalovirusCytomegalovirus is a major cause of congenital malformations and an important opportunistic pathogen in immunocompromised hosts.112 In transplant recipients, it may cause interstitial pneumonitis, fever–leukopenia syndromes, hepatitis, glomerulopathy, retinopathy, and other disorders, and may enhance susceptibility to superinfection with fungi, protozoa, and bacteria.113 , 114 It also causes a heterophil-negative mononucleosis syndrome in both immunocompetent and immunosuppressed hosts.115 , 116 No agent has shown clinical usefulness in the therapy of cytomegalovirus infection. Therapeutic trials in ongoing cytomegalovirus pneumonia have been carefully conducted in bone-marrow–transplant recipients in Seattle.117 , 118 Treatment with vidarabine, alpha interferon, acyclovir, and combinations of vidarabine and alpha interferon or of acyclovir . . .