PROBLEMS IN THE NATURAL HISTORY OF POLIOMYELITIS

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Abstract
Among the important problems listed are: (1) establish as unequivocally as possible by further studies on patients in the earliest stages after infection the extent to which the nasal mucosa and the oral secretions under ordinary, not artificial circumstances, may be a source of poliomyelitis virus; (2) determine the properties which permit certain strains of virus to multiply in the alimentary tract and the precise tissue components in which such multiplication occurs; (3) the factors which determine the limited multiplication or dissemination of the virus within the central nervous system in those with inappar-ent or nonparalytic infections; (4) the role of multiple immuno-logical types of the virus in determining the character of the disease resulting from reinfection; (5) the role of strains of virus of low virulence; (6) the role of extrahuman reservoirs of the virus in dissemination of infection; (7) the factors which determine the seasonal predominance of the disease.