Alteration of Rat Uterine Alkaline Ribonuclease and Ribonuclease Inhibitor Activity Following the Administration of Estradiol
- 1 January 1981
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 13 (01) , 50-53
- https://doi.org/10.1055/s-2007-1019165
Abstract
Rat uterine active and total alkaline RNase and inhibitor activity were measured following 2-6 h estradiol (E2) treatment of ovariectomized animals. Although active RNase data vary during the treatment period, a significant decrease below control level was observed 6 h after hormone administration. Simultaneously, E2 stimulated an increase in uterine RNase inhibitor activity of 18-50%. Hormonal increased uterine RNase inhibitor activity was blocked by treatment with cycloheximide. E2-stimulated RNase inhibitor activity may act in conjunction with a slow reduction in total RNase activity to stabilize the various species of uterine cytoplasmic RNA necessary for the anabolic activity of the hormone.This publication has 1 reference indexed in Scilit:
- Regional differences in ribonuclease content of rat and mouse kidneyBiochemical Journal, 1977