CLINICAL STAGE AND IMMUNOLOGICAL FINDINGS IN CHRONIC LYMPHOCYTIC-LEUKEMIA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 63  (1) , 50-56
Abstract
The total and T-lymphocyte counts, different types of lymphocytic surface Ig and levels of serum Ig were studied in 112 consecutive patients with chronic lymphocytic leukemia in order to investigate possible correlation between the immunological picture and the different stages. Patients were also subdivided according to the form of their disease, passive or active, and correlations with the immunological picture investigated. The total lymphocyte count showed a significantly increasing trend through the 3 different stages, (P < 0.01), and it was higher in the active than in the passive disease (P < 0.01). The number of T-lymphocytes increased in the active forms (P < 0.01). No statistically significant correlations were observed between the different surface Ig subclasses and the clinical pattern. In regard to the various classes of serum Ig, the number of patients, with a reduction of at least one of the classes tended to increase with worsening of the clinical stage.