Loss of transcriptional repression contributes to the ectopic expression of the calcitonin/α‐CGRP gene in a human lung carcinoma cell line
- 20 July 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 306 (2-3) , 229-233
- https://doi.org/10.1016/0014-5793(92)81006-8
Abstract
The calcitonin/α‐CORP (CT/CGRP) gene is ectopically expressed in a wide variety of neoplasia. We have investigated the molecular mechanisms responsible for this ectopic expression in the human cell line BEN, which is derived from a poorly differentiated squamous cell lung carcinoma. We show that a trans‐acting factor which represses expression of the CT/CGRP gene in HeLa cells is absent or inactive in BEN cells, and have localised the repressor binding site to a 53 bp fragment 1500 bp upstream of the transcription start site.Keywords
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