Optimal Intracellular Calcium Signaling
- 24 January 2002
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 88 (6) , 068102
- https://doi.org/10.1103/physrevlett.88.068102
Abstract
In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding). These channels are clustered with a typical cluster size of about 20 channels, generating stochastic calcium puffs. We find that the clustering of the release channels in small clusters increases the sensitivity of the calcium response, allowing for coherent calcium responses at signals to which homogeneously distributed channels would not respond.Keywords
This publication has 25 references indexed in Scilit:
- Hierarchical organization of calcium signals in hepatocytes: from experiments to modelsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000
- Stochastic spreading of intracellularreleasePhysical Review E, 2000
- Spark-to-wave transition: saltatory transmission of calcium waves in cardiac myocytesBiophysical Chemistry, 1998
- Fundamental calcium release events revealed by two‐photon excitation photolysis of caged calcium in guinea‐pig cardiac myocytesThe Journal of Physiology, 1998
- Calcium oscillations increase the efficiency and specificity of gene expressionNature, 1998
- Sensitivity of CaM Kinase II to the Frequency of Ca 2+ OscillationsScience, 1998
- Imaging the hierarchical Ca2+ signalling system in HeLa cells.The Journal of Physiology, 1997
- A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.Proceedings of the National Academy of Sciences, 1992
- Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial SignalingScience, 1990
- Minimal model for membrane oscillations in the pancreatic beta-cellBiophysical Journal, 1983