Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives
- 1 January 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (1) , 50-59
- https://doi.org/10.1021/jm00175a010
Abstract
More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, .alpha.-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent possessed hypolipidemic activities higher than or comparable to that of clofibrate. The proper length (C12-C16) and the para position of the alkoxy substituent seem essential for activity. Chloroethyl and methacryloxyethyl esters and monoglycerides of some active p-alkoxycinnamic acids were more active than the corresponding free acids.This publication has 0 references indexed in Scilit: