Chromosome-Encoded Class D β-Lactamase OXA-23 in Proteus mirabilis
Open Access
- 1 June 2002
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (6) , 2004-2006
- https://doi.org/10.1128/aac.46.6.2004-2006.2002
Abstract
Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 μg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a blaOXA-23 probe showed that the gene was chromosome encoded in the P. mirabilis strain.Keywords
This publication has 27 references indexed in Scilit:
- Characterization of OXA-25, OXA-26, and OXA-27, Molecular Class D β-Lactamases Associated with Carbapenem Resistance in Clinical Isolates of Acinetobacter baumanniiAntimicrobial Agents and Chemotherapy, 2001
- A Novel Class A Extended-Spectrum β-Lactamase (BES-1) in Serratia marcescens Isolated in BrazilAntimicrobial Agents and Chemotherapy, 2000
- Prevalence of β-Lactamases among 1,072 Clinical Strains of Proteus mirabilis : a 2-Year Survey in a French HospitalAntimicrobial Agents and Chemotherapy, 2000
- Sequence Analysis of ARI-1, a Novel OXA β-Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92Antimicrobial Agents and Chemotherapy, 2000
- Oxacillin-hydrolyzing β-lactamase involved in resistance to imipenem in Acinetobacter baumanniiFEMS Microbiology Letters, 1997
- Oxacillin-hydrolyzing β-lactamase involved in resistance to imipenem in Acinetobacter baumanniiFEMS Microbiology Letters, 1997
- Imipenem resistance in clinical isolates of Proteus mirabilis associated with alterations in penicillin-binding proteinsJournal of Antimicrobial Chemotherapy, 1995
- A functional classification scheme for beta-lactamases and its correlation with molecular structureAntimicrobial Agents and Chemotherapy, 1995
- Imipenem resistance in Proteus mirabilisJournal of Antimicrobial Chemotherapy, 1991
- Computerized microacidimetric determination of β lactamase Michaelis—Menten constantsFEBS Letters, 1973