INVITRO STIMULATION OF BOVINE PERIPHERAL-BLOOD LYMPHOCYTES - SUPPRESSION OF PHYTOMITOGEN AND SPECIFIC ANTIGEN LYMPHOCYTE-RESPONSES BY AFLATOXIN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (12) , 2033-2035
Abstract
Effects of aflatoxin B1 on responses of peripheral blood lymphocytes (PBL) of 2 normal animals to phytohemagglutinin, concanavalin-A and pokeweed mitogen as well as of PBL of 2 Mycobacterium bovis-infected animals to phytohemagglutinin and purified protein derivative of M. bovis (PPD) were studied. Aflatoxin concentrations of .gtoreq. 10 .mu.g/ml significantly suppressed lymphocyte response of normal animals to phytomitogens. Lymphocyte response of M. bovis-infected animals to specific antigen PPD was significantly suppressed at aflatoxin concentration of 0.5 .mu.g/ml. Higher concentrations [50- to 100-fold] of aflatoxin were required to produce 50% suppression of lymphocyte response to phytomitogens, as compared with that produced to PPD.

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