Detection of Metastatic Tumors in Nude Mice: Brief Communication2
- 1 March 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 60 (3) , 715-716
- https://doi.org/10.1093/jnci/60.3.715
Abstract
Homozygous nude (nu/nu) mice were inoculated ip with either highly malignant human bladder transitional cell carcinoma or human prostate adenocarcinoma. These animals were subsequently given injections of normal human T-lymphocytes to restore the known T-lymphocyte deficiency present in homozygous nude mice. Metastatic spread of the prostate and bladder carcinomas was evident In mice given human T-lymphocytes. Although tumor growth was observed at the sites of tumor inoculation, no tumor spread was observed in mice not receiving T-lymphocytes.Keywords
This publication has 2 references indexed in Scilit:
- lmmunobiology of Heterotransplanted Human Tumors in Nude Mice2JNCI Journal of the National Cancer Institute, 1977
- SYNGENEIC METASTATIC TUMOR MODEL IN MICE - NATURAL IMMUNE-RESPONSE OF HOST AND ITS MANIPULATION1976