Abstract
The intra-peritoneal injection of DL-ethionine was found to have the following effects on carbohydrate metabolism: (1) decrease in liver glycogen in both male and female rats given glucose by stomach tube,(2) decrease in liver glycogen in male and female rats given glucose subcutaneously, (3) increase in glucose unabsorbed from the alimentary tract in male and female rats given by stomach tube,(4) decrease in liver glycogen in female rats given glucose by stomach tube or subcutaneously 3 hours prior to administration of ethionine. Female rats generally showed changes of greater magnitude than males under the same conditions. Methionine prevented in part some of the effects on liver glycogen but had an effect similar to ethionine on glucose absorption from the alimentary tract.

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