The Effect of Carrageenan on Delayed Hypersensitivity Reactions
Open Access
- 1 July 1969
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 103 (1) , 87-91
- https://doi.org/10.4049/jimmunol.103.1.87
Abstract
Administration of carrageenan to tuberculin-sensitive guinea pigs resulted in a dose-dependent suppression of delayed hypersensitivity. Recovery was complete 1 week after drug administration. The suppressive activity was not correlated with anticomplementary or anticoagulant activity. It is suggested that carrageenan exerts its effect as a result of its toxicity for macrophages, acting through lysosomal damage and the release of intracellular enzymes.Keywords
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