Effect of Domperidone, an Extracerebral Inhibitor of Dopamine Receptors, on Thyrotropin, Prolactin, Renin,Aldosterone, and 18-Hydroxycorticosterone Secretion in Man

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Abstract
The dopaminergic mechanisms involved in the control of corticosteroid secretion were investigated in normal subjects. TSH, PRL [prolactin], PRA [plasma renin activity], aldosterone and 18-hydroxycorticosterone (18-OHB) were measured before and after the administration of domperidone (10 mg, i.v.) to 8 healthy males. Domperidone, a selective peripheral dopamine antagonist, stimulated TSH and PRL secretion. Plasma concentrations of aldosterone, 18-OHB, cortisol and PRA were not altered by domperidone. This is in contrast to previous observations of aldosterone, 18-OHB and PRA responses to metoclopramide, a dopamine antagonist which readily crosses the blood-brain barrier. Domperidone may fail to stimulate aldosterone, 18-OHB and renin secretion because it does not cross the blood-brain barrier or does not function as an antagonist for adrenal dopamine receptors modulating 18-OHB and aldosterone secretion.

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