Increased Work of Breathing Associated with Nasal Prongs

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Abstract
To determine if continuous distending pressure (CDP) given by nasal prongs increases work of breathing, the mechanics of breathing, minute ventilation and blood bases were measured in 9 infants with both nasal prong and face mask CDP. Minute ventilation was 16% larger (P < .02), work of breathing was 94% higher (P < .01) and the mean PaO2 [arterial O2 pressure] was 8 mm Hg lower (P < .03) with the nasal prongs. There was no difference in pH or PaCO2 [arterial CO2 pressure]. CDP given by nasal prongs may increase the risk of respiratory failure in the premature infant already compromised with hyaline membrane disease.