Studies on the Toxicity of β-Dihydroheptachlor

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Abstract
[beta]-Dihydro-heptachlor has a low toxicity to mammals and birds. Rats and dogs were shown to survive single oral doses of 5 g/kg and fowl survive single oral doses of 2 g/kg. Rats survived 15 g/kg given by oral administration over a period of 3 weeks. No effects could be detected in rats exposed to dietary concentrations of up to 3160 ppm for a period of 90 days. However, exposure of mice to 1000 ppm for 90 days produced 10 deaths in 24 animals exposed. Changes in liver weight and histology were also apparent. The biological half-life of [beta]-dihydrohepatchlor in male mice was estimated as 4 days and as 8-10 days in the eggs of exposed birds. No symptoms indicative of organo-chlorine insecticide intoxication were seen in animals exposed by the oral route. Typical symptoms could, however, be produced in rats by the intravenous injection of the compound in a cotton seed oil emulsion.

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